Disulfiram is used for the treatment of chronic or long-term alcohol dependence. Always take this medication exactly as prescribed by your doctor. The dosage depends on the strength of the medicine and the patient’s medical condition. Do not take more than the recommended dose, and do not take it more frequently than advised.
Directions for Use
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Swallow the tablet whole with a full glass of water.
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Do not break, crush, or dissolve the tablet.
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Take your dose at the same time every day to avoid missing doses.
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Do not stop the medication or change the dose without consulting your doctor.
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This medicine is meant to be taken regularly for best results—continue using it for as long as your doctor recommends.
Severe liver problems, and in rare cases even liver failure leading to death, have been reported in patients taking Disulfiram, even among those with no prior history of liver disease.
Seek immediate medical help or contact your doctor if you experience:
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Difficulty breathing
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Swelling of the face, lips, tongue, or throat
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Skin hives or severe allergic reactions
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Extreme fatigue or severe weakness
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Dark-colored urine
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Seizures
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Yellowing of the skin or eyes (jaundice)
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Major changes in appetite
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Severe diarrhea or vomiting
Esperal 250 mg Tablet is prescribed by healthcare professionals for the treatment of chronic alcoholism. Its active ingredient is Disulfiram, a drug discovered in 1920 to help manage alcohol dependence. Disulfiram works by creating an increased sensitivity to alcohol in the body. When a person consumes alcohol while taking this medication, it triggers unpleasant physical reactions such as vomiting, sweating, anxiety, difficulty breathing, and choking sensations.
These effects discourage alcohol consumption by making the drinking experience highly uncomfortable. However, it is important to note that Esperal does not cure alcoholism—it simply helps reduce the desire to drink and supports recovery when used along with counseling and lifestyle changes.
Consuming alcohol while undergoing treatment with Disulfiram (Esperal) can lead to serious reactions such as rapid heartbeat, flushing, excessive thirst, nausea, chest pain, low blood pressure, or dizziness/vertigo. It is recommended to avoid taking Disulfiram for at least 12 hours after drinking alcohol.
Even after discontinuing Disulfiram, its effects may persist for several weeks, meaning alcohol consumption during this period can still trigger adverse reactions.
While on Disulfiram therapy, it is important to stay alert about hidden sources of alcohol found in everyday products such as:
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Cough syrups and tonics
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Mouthwash and oral rinses
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Sauces, vinegar, and fermented foods
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Certain desserts and flavoring extracts
Always read product labels carefully, as even small amounts of alcohol may interact dangerously with Disulfiram.
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