Details : Spironolactone is the generic version for Aldactone 50 mg. It can treat high blood pressure. It can also treat fluid retention (edema) and high levels of the hormone aldosterone. Aldosterone Receptor Antagonists, An antimineralocorticoid, also known as a mineralocorticoid receptor antagonist or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.